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  • STATIN NATION: The Great Cholesterol Cover-Up
    STATIN NATION: The Great Cholesterol Cover-Up
    Rethink Productions
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    Sunday
    Oct132013

    British National Press Does it Again with Extremely Misleading Article

    This weekend, at least 3 national newspapers here in the UK (the Daily Mail, the Telegraph, and the Mirror) printed an article suggesting that cholesterol-lowering statin medications had led to a 40% reduction in strokes in Britain.

    Based on what was written in these newspapers, it was initially a little time consuming to find the actual published research they are referring to – this is because their description of the stroke reduction being attributed to statins didn't match any of the published studies in the medical literature. As far as I can establish, they are referring to this study:

    Yanzhong Wang, Anthony G. Rudd and Charles D.A. Wolfe. Trends and Survival Between Ethnic Groups After Stroke: The South London Stroke Register. Stroke 2013;44:380-387

    Although the 3 newspapers state that statins have been the main factor, there is no evidence of this whatsoever in the above study. There is only one reference to statins in the study itself, which reads:

    “There are limitations in our study. We do not have cholesterol/pathology data in our stroke register but we do have use of statins. “

    That's it. There is no further mention of statins or any mention of the impact statins might or might not have had.

    So, the national press has just plucked this headline out of thin air. Or maybe this article came about as a result of a press release from the drugs companies or an organisation which supports the drugs companies? Who knows? Wherever it came from, it has deeply misled the general public.

     

    This is not the first time this has happened, I wrote about a similar case at the end of last year, available here.

    Its no wonder that many people are confused about this issue.

    Thursday
    Sep052013

    Vascular Surgeons Write a Damming Report About Statins

    Two top vascular surgeons have published a damming report on statin medications. 

    Dr Sherif Sultan, Consultant Vascular and Endovascular Surgeon, Honorary Senior Lecturer at NUI Galway, Ireland, and Dr Niamh Hynes, Clinical Lecturer In Vascular & Endovascular Surgery at Western Vascular Institute, Ireland have conducted a critical review of the benefits and risks associated with statin medications.

     

    In summary, their paper highlights the following key points: 

    • Not only are statin medications failing to impact on our most prevalent disease, but they are causing more harm than good.
    • Cholesterol is crucial for energy, immunity, fat metabolism, leptin, thyroid hormone activity, liver related synthesis, protection from stress, adrenal function, sex hormone syntheses and brain function. 
    • Only middle aged men with coronary heart disease benefit from taking statins, but even in these cases statins may only work in the short term and should be stopped before adverse effects can take hold.
    • High cholesterol levels have been found to be protective in elderly and heart failure patients.
    • The statin industry is the utmost medical tragedy of all times. 
    • A government report in Canada found an overestimation of benefit and underestimation of harm where statins are concerned.
    • Statins are associated with triple the risk of coronary artery and aortic calcification.

    This is another scientific paper that should immediately stop the widespread prescription of statins, however, it has gone almost completely unnoticed. In fact, I only became aware of it because it was sent to me from my friend Clare Harris from the Stopped Our Statins support group.

     

    You can read the full paper here.

    Thursday
    Aug292013

    New Study Confirms Statins Do Not Save Lives

    A 'new' study of statin medications has just been published in the Journal of the American College of Cardiology. I say new, but actually its a new manipulation of old data.  

    The researchers looked at eight previously conducted clinical trials done on statins. The population studied was elderly people without existing cardiovascular disease. After doing their calculations, it was concluded that statins did slightly reduce the risk of heart attack and stroke, but the use of statins did not reduce the risk of death from cardiovascular disease. There was also no reduction in the risk of death from all causes.

    The bottom line is that it has once again been established that statins do not extend life expectancy for people without cardiovascular disease.

    This is one of the key points that STATIN NATION exposes.  The video excerpt below provides a summary of this issue:

    A Bit More Detail

    Around 75% of all the people who take a statin, are taking it for  primary prevention. This means they do not have a heart problem but are taking the medication in the hope of preventing a heart problem in the future.  When it comes to primary prevention none of the largest clinical trials have been able to conclusively show any net benefit.

    The AFCAPS (1), ASCOT (2), CARDS (3), PROSPER (4) and WOSCOPS (5) clinical trials all failed to show a statistically significant reduction in all cause mortality (deaths from all causes, not just heart disease related deaths).

    All cause mortality data, of course, is the only true measure one can use to determine if a statin is going to extend life expectancy or not. Whilst some clinical trials of statins have shown a very slight reduction in heart disease, in primary prevention, this has always been countered by deaths from other causes. The net result is that people do not live any longer after taking a statin.

    In 2010, a meta-analysis of 11statin trials was published in the Archives of Internal Medicine. Professor Kausik Ray and colleagues concluded that statins provided no benefit in terms of deaths from all causes, when used for primary prevention (6). This analysis had the “cleanest” dataset of any analysis completed to date - the researchers were able to exclude patients with existing heart disease (known as secondary prevention) and only include data associated with primary prevention.

    When we look at the use of statins for people who already have a diagnosed heart problem (the 25% of people, in secondary prevention) the picture becomes less clear cut. Some trials have found significant increases in life expectancy for these people, however, the trials have always been too short for us to assess the long-term impact of being on a statin. 

    Even if statins do provide a short-term benefit for those with a heart problem, it is unlikely that this has anything to do with the cholesterol-lowering effect of statins. Quite simply, the amount of benefit does not match up with the degree of cholesterol-lowering. The potential beneficial affects of statins for people with heart disease is now widely recognised to be associated with a reduction in inflammation. And recent evidence suggests that this is mediated through an improvement in iron metabolism (7).

    “Benefits Outweigh Risks” 

    Any decision to take a medication should of course involve a clear understanding of the benefits balanced against the risks. Many authorities have repeatedly stated that the benefits of statins far outweigh the risks. Clearly, this is not correct.

    First of all, as we have seen above, there is no net benefit for the 75% of people who take a statin in primary prevention. So, for these people, the choice should be abundantly clear, since they will only expose themselves to the significant adverse effects associated with statins.  

    Statins have been linked with more than 300 different adverse effects. The most common adverse effects include: depression, suicide, sleep disturbances, memory loss, sexual dysfunction, lung disease, muscle-related problems, cognitive loss, neuropathy, pancreatic dysfunction and liver dysfunction. More recent studies have also shown that statins cause type 2 diabetes and acute kidney injury.

    In addition, many doctors are concerned about statins and a potential increase in the risk for cancer and heart failure. A recent study found that the long term use of statins doubles the risk of breast cancer in women.

    The best estimates suggest that at around 20% of the people who take a statin will experience significant adverse effects. This needs to be considered when thinking about both primary and secondary prevention, since this 20% is a much greater number than the number of people who might benefit, even in secondary prevention. 

     

    References: 

    1. Downs JR, et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA 1998; 279:1615-22.

    2. Sever PS, et al. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet 2003; 361:1149-1158.

    3. Clhoun HM, et al. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atovastatin Diabetes Study (CARDS). Lancet 2004; 364:685-696.

    4. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet 2002; 360:1623-1630.

    5. Shepherd J, et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia (WOSCOPS). N Engl J Med 1995; 333:1301-1307.

    6. Ray KK, et al. Statins and all-cause mortality in high-risk primary prevention: a meta-analysis of 11 randomized controlled trials involving 65,229 participants. Arch Intern Med. 2010; 170:1024-31.

    7. Zacharski, LR et al. The Statin–Iron Nexus: Anti-Inflammatory Intervention for Arterial Disease Prevention. American Journal of Public Health. Published online ahead of print February 14, 2013.

     

    Saturday
    Mar162013

    Fascinating Presentation from Allan Savory

    Fascinating TED presentation from Allan Savory. Dispelling the myth that Animals are bad for the environment. Personally, I remain open-minded about the suggestion that CO2 drives planetary warming, however, there are many many other good reasons why we should increase cattle – this would not only turn desert land back into pasture but also lift millions of people out of hunger and poverty. 

    Thursday
    Mar142013

    Statin Nation Fact Sheet 1

     

    Here is the first of a series of fact sheets to accompany the film Statin Nation.

    Please take this information to your doctor!

    Download it here.